The Phenomenon of Senile Resistance: The Role of Chronic Inflammation in Elderly Patients

Population aging is one of the key medical and social challenges of our time. According to projections, by 2050 the number of people aged 60 years and older will reach 2 billion, accounting for more than 20% of the total population.

In clinical practice, there is a well-known phenomenon is observed: some elderly patients retain functional independence despite taking five or more medications, while others experience decompensation even with minimal drug burden (two to three drugs). In gerontology, the term senile resistance is used to describe this phenomenon—the ability of the organism to resist the accumulation of age-related pathological changes and maintain systemic homeostasis under conditions of external and internal stressors. However, the molecular and physiological mechanisms underlying this phenomenon remain the subject of active investigation.